When your patient’s current depression therapy isn’t enough... ADD THE M[]SSING PEACE

How DEPLIN® Works

L-methylfolate is the biologically active form of folate and is involved in neurotransmitter synthesis. L-methylfolate modulates the synthesis of monoamines.

See how the active form of folate in DEPLIN® enhances neurotransmitter production to help antidepressant effectiveness.1-6



DEPLIN®: Targeted nutrition to help brain neurochemistry and antidepressant work better together7

*DEPLIN® is the only product with 15 mg of Metafolin® (L-methylfolate calcium), which is clinically proven and has been widely studied in over 25 clinical trials.

DEPLIN® is designed to address specific nutritional deficiencies in patients with depression.1-3


DEPLIN® contains L-methylfolate, an active form folate that crosses the blood-brain barrier to regulate the production of dopamine, norepinephrine, and serotonin.1-6


DEPLIN® restores neurotransmitter levels, helping to optimize the effect of antidepressant.7


In clinical trials, DEPLIN® has adverse events similar to placebo, no significant difference in discontinuation and is not associated with weight gain or sexual dysfunction.5

See the Folate Story

See the Folate Story

Discover the DEPLIN® Difference

Discover the DEPLIN® Difference

Is DEPLIN® Safe and Well Tolerated?

An Expert’s Perspective

BRAND DIRECT HEALTH

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Request additional information from your DEPLIN® Representative

Your DEPLIN® representative can provide more information about how DEPLIN® can help patients who have an inadequate response to their current depression therapy.

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*Based on US dollar sales through IQVIA NSP reporting channels from October 2021-September 2023 of Deplin® compared to other branded medical foods indicated for Depression.

References: 1. Stahl SM. CNS Spectr. 2007;12(10):739-744. 2. Bottiglieri T. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-1112. 3. Spector R, Lorenzo AV. Am J Physiol. 1975;229(3):777-782. 4. Stahl SM. J Clin Psychiatry. 2008;69(9):1352-1353. 5. Papakostas GI, Shelton RC, Zajecka JM, et al. Am J Psychiatry. 2012;169(12):1267-1274. 6. DEPLIN [package insert]. Shreveport, LA: Alfasigma USA, Inc.; 2024. 7. Liwinski T, Lang UE. Nutrients. 2023;15(17):3859.

DEPLIN® is a medical food for use only under medical supervision for the clinical dietary management of depression and schizophrenia and is specially formulated to meet the distinctive nutritional requirement for these condition.

Manufactured and Distributed by:
Alfasigma USA, Inc.
Shreveport, LA 71104
© 2024 Alfasigma USA, Inc.


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