Healthcare Professionals
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Deplin® helps your brain and antidepressant work better together

Targeted nutrition for people with depression

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See how nutrients can support mood.

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What is Deplin®?

Deplin® is targeted nutrition that provides an essential nutrient your body can’t get through diet alone to help restore brain chemistry balance. This allows your brain and antidepressant to work better together for more effective symptom relief.1 Deplin® is prescribed for use under medical supervision.

How Nutrition Impacts Mood

Proper nutrition plays a key role in mood and brain function. Nutrient deficiencies can interfere with cognitive performance and emotional well-being. Without the right nutrients, antidepressants may not work optimally, and side effects may increase. Addressing these deficiencies helps restore brain chemistry balance and supports recovery.2

Is Deplin® Right For You?

Deplin® is the #1 prescribed medical food brand for depression*. Ask your healthcare provider if Deplin® should be added to your current depression care.

Free & Clear

Deplin® offers Deplin FC™, a free and clear formula that provides 15mg of L-methylfolate to help your brain and antidepressant work better together.1,4

84% Symptom Reduction

In a clinical study, adding Deplin FC™ reduced depressive symptoms by up to 84% vs antidepressant alone. 3

No Added Side Effects

Safety profile is similar to placebo and not associated with weight gain or sexual dysfunction. 13

Deplin® & Depression Resources

Patient Resources

Download a discussion guide to start the conversation with your provider, and find other resources on Deplin® and depression.
See Patient Resources

Request a Prescription

If you’re using an antidepressant but still not feeling your best, connect with a provider via telehealth to see if Deplin® can help you.
Request a Prescription
Get a Prescription

Deplin®/Deplin FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression and schizophrenia. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) is free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of Deplin® branded medical foods compared to other branded medical foods indicated for depression.

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  2. Mrozek W, et al. Nutrition. 2023:112143.
  3. Papakostas G, et al. Am J Psychiatry. 2012;169:1267-1274.
  4. Lam NSK, et al. Biomedicine & Pharmacotherapy. 2022;146:112541.
  5. Fava M, Mischoulon D. J Clin Psychiatry.2009;70(suppl 5):12-17.
  6. Nakazato M. et al.Eur J Nutr. 2011; 50:581–585.
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  15. Shelton RC, et al. Prim Care Companion CNS Disord. 2013 Aug 29;15(4). https://pmc.ncbi.nlm.nih.gov/articles/PMC3869616/
  16. Sarris J. et al. World J Biol Psychiatry. 2022;23(6):424-455.
  17. Lam RW, et al. Can J Psychiatry. 2024 May 6:1-47