Healthcare Professionals
DeplinPRO Mood Health™

DeplinPRO Mood Health™

A New Step in Your Depression Care

Depression isn’t caused by one single thing — it’s shaped by many factors that affect how your brain works. DeplinPRO Mood Health™ brings together four key nutrients in a multi-action formula that helps restore the biological balance needed for mood, stress, and cognitive function — supporting your ongoing depression care.

Ingredients

L-Theanine (γ-Glutamylethylamide), Vegetarian Capsule (Hypromellose, Black Iron Oxide), Zinc Bisglycinate (as Chelamax®), Vitamin D3 Powder (Cholecalciferol), L-Methylfolate Calcium (as Metafolin®), Magnesium Stearate, Silicon Dioxide.


Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany. Chelamax® is a registered trademark of Innophos, New Jersey, USA.


Manufactured & Distributed by: Alfasigma USA, Inc., Shreveport, LA 71103

Directions & Dosage

Adults and children 12 years of age and older, take one capsule daily or as directed by your healthcare provider.


DeplinPRO Mood Health™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of mood disorders. Use under medical supervision.


Available in 90-count packages.

Warnings & Storage

Keep out of reach of children. If you are pregnant or nursing, consult with your healthcare provider before taking.


Store at a controlled room temperature of 59°F to 86°F (15C to 30C). Protect from heat, light and moisture.

Addressing 5 Key Factors of Depression Management

Together, the ingredients in DeplinPRO Mood Health™ work to support:
Emotional Balance1,3-5
Helps maintain neurotransmitter activity — the brain chemicals that influence how you feel.
Brain Cell Wellness1,5-9
Provides nutrients that help protect brain cells from everyday oxidative stress and support normal cell function.
Mental Resilience8,10,11
Supports the hormones and signals that help your brain adapt to stress and regain emotional stability.
Stress Management4,6,10
Supports the brain’s natural response to everyday stress, promoting calm and focus.
Cognitive Function5,6,10,12
Supports neuroplasticity — the brain’s ability to form and strengthen connections — to aid memory and clear thinking.

The Clinical Impact of Adding DeplinPRO Mood Health™

Clinical studies of the ingredients in DeplinPRO Mood Health™ show meaningful results in depression care and report that these nutrients are safe and well-tolerated.

1 in 2

People achived remission at month 12 when adding 15mg L-methylfolate to an SSRI.32*

90% Symptom Improvement

Clinically shown to improve depressive symptoms by 90% when taking Vitamin D3 & zinc together.30

3 hours

Time it took a single 200 mg dose of L-theanine to promote a feeling of relaxation. 31

Safe & Well Tolerated

Multiple studies show ingredients support mood & brain health with minimal side effects.10,29-33
*Studied on the DEPLIN® formula, containing the same level of L-methylfolate as DeplinPRO Mood Health™.

Meet the 4 Nutrients that Power DeplinPRO Mood Health™

L-Methylfolate

L-Methylfolate

The active form of folate — a nutrient that helps your brain make important mood-related chemicals like serotonin, norepinephrine, and dopamine.1,3


Supports: Mood balance and emotional well-being

Vitamin D3
Yellow vitamin D3 supplement with 'D3' label

Vitamin D3 (Cholecalciferol)

Known as the “sunshine vitamin,” vitamin D₃ helps keep brain cells functioning properly and works with zinc to support mood regulation.4,6,7,34,35


Supports: Emotional balance and overall brain health

Zinc

Zinc (zinc bisglycinate)

An essential mineral your body uses for brain signaling and stress response. Zinc helps support communication between brain cells and the hormones that influence mood.5,8,36,37


Supports: Stress response and mood stability

L-Theanine
Molecular structure diagram depicting L-Theanine with yellow atoms and purple leaves on a white background

L-Theanine (γ-glutamylethylamide)

A naturally occurring amino acid found in green tea that helps promote calm focus and relaxation.9,10,38,39


Supports: Relaxation, focus, and resilience during stress

Building on the Science of DEPLIN®

For more than 15 years, DEPLIN® has provided targeted L-methylfolate nutrition for people with depression. DeplinPRO Mood Health™ builds on that foundation with a multi-nutrient formula designed to work across multiple biological pathways involved in mood, stress, and cognitive function — helping support your brain’s ability to respond effectively to treatment.

No Major Allergens or Unnecessary Additives

DeplinPRO Mood Health™ contains safe and well-tolerated ingredients that aren’t associated with the typical side effects of depression medications. It contains no unnecessary dyes, fillers, or additives.

Getting Deplin FC™ through Brand Direct Health® Pharmacy is easy

  • Everyday low price
  • Flexible payment options
  • 100% money-back guarantee
  • FSA/HSA eligibility
  • Brand Direct Health® Pharmacy orders only, as compared to the everyday retail price through GoodRx (accessed on 6/24/2024).
    Limited to 1 refund per person, per product. Excludes shipping and convenience fees.

Deplin FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression & schizophrenia. Use under medical supervision.

DeplinPRO Mood Health™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of mood disorders. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) and DeplinPRO Mood Health™are free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of Deplin® branded medical foods compared to other branded medical foods indicated for depression.

§Real testimonials. Pictures and names are for illustrative purposes only.

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