DEPLIN® is a trusted medical food brand designed to help address neurotransmitter imbalances. It provides targeted nutrition to help restore brain chemistry balance, enhancing the effectiveness of antidepressants and promoting emotional well-being.1,3,6,8,10,13 DEPLIN® currently offers two products: DeplinPRO Mood Health™ and Deplin FC™.
DEPLIN® is ideal for people ages 12 and up who are dealing with depression, particularly those who may benefit from additional support to balance neurotransmitters and optimize antidepressant effectiveness. Deplin FC™ provides L-methylfolate, a key nutrient needed for the brain’s production of neurotransmitters involved in mood regulation.1,3 DeplinPRO Mood Health™ builds upon that foundation with added vitamin D3, zinc and L-theanine to deliver a more comprehensive impact across multiple neurological pathways involved in depression.1,3-8,34,39
Not all forms of folate work the same way in the body. Typical folic acid supplements must be converted through several steps before the brain can use them — a process that may not work efficiently in many people due to genetic or metabolic differences.
DEPLIN® products contain L-methylfolate, the active form of folate that can cross the blood–brain barrier and be used directly to support neurotransmitter production involved in mood regulation.1 Because of this targeted activity, DEPLIN® is sold by prescription and intended for use under medical supervision as part of ongoing depression care.
Deplin FC™ is targeted nutrition that provides L-methylfolate—an active form of folate that supports mood regulation. This formula is free from unnecessary additives or major allergens† and is available in both 7.5mg and 15mg capsules sold by prescription for people aged 12 years and older.
DeplinPRO Mood Health™ continues the legacy of Deplin FC™ with an expanded multi-nutrient formula. It combines L-methylfolate—the same active form of folate found in Deplin FC™—with vitamin D₃, zinc, and L-theanine to support multiple biological pathways involved in mood, stress, and cognitive health. This formula is free from unnecessary additives or major allergens* and is sold by prescription for people aged 12 years and over.
*Major allergens such as fish, shellfish, wheat, eggs, milk, tree nuts, peanuts, soy, and sesame.
DEPLIN® products are medical foods sold by prescription and should be used under medical supervision. You can find a healthcare provider near you or use our downloadable discussion guide to talk to your current healthcare provider about adding DEPLIN® to your care plan. If you already have a prescription, you can easily fill it through Brand Direct Health® Pharmacy.
Yes, you can save on DEPLIN® with Brand Direct Health® Pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health® Pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.
DEPLIN® products are medical food that provide targeted nutritional support for the biological processes that influence mood. Both Deplin FC™ and DeplinPRO Mood Health™ deliver L-methylfolate—the active form of folate your brain uses to produce neurotransmitters like serotonin and dopamine, which help regulate mood.1,3
By helping restore brain chemistry, DEPLIN® products support your brain’s ability to respond more effectively to treatment. DeplinPRO Mood Health™ builds on this foundation with additional nutrients—vitamin D₃, zinc, and L-theanine—that further support mood, stress, and cognitive health. 4-8,34,39
Yes, DeplinPRO Mood Health™ and Deplin FC™ are designed to help address nutrient deficiencies associated with depression and to complement your antidepressant by helping restore brain chemical balance and supporting the biological processes your brain needs to respond effectively to treatment—without added side effects.10,29-33
DEPLIN® products help build the biological foundation your brain needs in order to get the most out of antidepressant treatment. Clinical studies of L-methylfolate—the key nutrient in Deplin FC™ and DeplinPRO Mood Health™—show that people notice improvements in mood within 30 days and more than half achieved remission by 12 months.29,32 Everyone’s experience is different, so it’s important to stay consistent and work with your healthcare provider to track your progress.
Both DeplinPRO Mood Health™ and Deplin FC™ contain ingredients that have been shown to be safe and well-tolerated in clinical studies. While DeplinPRO Mood Health™ as a specific formulation has not yet been clinically evaluated, its individual nutrients have each demonstrated strong safety in published research.
DEPLIN® products are not associated with side effects such as weight gain, sleep disturbances, or sexual dysfunction,29 making them a safe option to add to your ongoing depression care routine.
The length of time you may need to take DEPLIN® products depends on your individual needs. Many people use it long-term alongside antidepressants to maintain brain health and support mood balance. In clinical studies of L-methylfolate—the foundational ingredient in Deplin FC™ and DeplinPRO Mood Health™—ongoing use over 12 months was associated with sustained improvement in mood.29,32 Your healthcare provider can help determine the best plan for you.
DeplinPRO Mood Health™ and Deplin FC™ are free from major allergens such as fish, shellfish, wheat, eggs, milk, tree nuts, peanuts, soy, and sesame. They are also non-GMO and free from dyes, sugar, titanium dioxide, or preservatives.
Yes. The safety of L-methylfolate—the primary nutrient in both Deplin FC™ and DeplinPRO Mood Health™—has been well established in clinical studies, showing a safety profile similar to placebo.29,32
While DeplinPRO Mood Health™ as a specific formulation has not yet been clinically evaluated, its additional nutrients (vitamin D₃, zinc, and L-theanine) have each been shown in published studies to be safe and well-tolerated.10,33 The most commonly reported side effects are mild stomach symptoms, such as discomfort, which usually go away on their own.
As with all DEPLIN® products, use should be under medical supervision as part of ongoing nutritional management for depression.
DeplinPRO Mood Health™ contains L-methylfolate calcium, vitamin D3 (cholecaliferol), zinc bisglycinate, and L-theanine (γ-glutamylethylamide). Deplin FC™ contains L-methylfolate calcium. Both products include other ingredients for formulation stability.