Deplin® is a trusted medical food brand designed to address neurotransmitter imbalances. It provides targeted nutrition to help restore brain chemistry balance, enhancing the effectiveness of antidepressants and promoting emotional well-being.1,4,5
Deplin® is ideal for people dealing with depression, particularly those who may benefit from additional support to balance neurotransmitters and optimize antidepressant effectiveness.
Deplin® provides L-methylfolate, the active form of folate, which your brain can use immediately without needing to be converted. Since up to 70% of people with depression may have a genetic variation that affects their ability to convert folic acid into its active form,14 Deplin® helps ensure your brain gets the nutrients it needs efficiently.
Currently, Deplin® offers the Deplin FC™ formula, which provides L-methylfolate—an active form of folate that supports mood regulation. This formula is free from unnecessary additives or major allergens such as fish, shellfish, wheat, eggs, milk, tree nuts, peanuts, soy, and sesame, and is available in both 7.5mg and 15mg capsules.
Deplin® is a medical food sold by prescription and should be used under medical supervision. If you're already on an antidepressant, you can request a prescription online through telehealth, where a healthcare professional can assess your needs and potentially prescribe Deplin®. Alternatively, you can find a healthcare provider near you or use our downloadable discussion guide to talk to your current healthcare provider about adding Deplin® to your care plan. If you already have a prescription, you can easily fill it through Brand Direct Health® Pharmacy.
Yes, you can save on Deplin® with Brand Direct Health® Pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health® Pharmacy, call 1-866-331-6440, Monday - Friday 8am - 8pm ET or visit www.branddirecthealth.com to learn more.
Deplin® provides targeted nutrition to help address neurotransmitter imbalances that may contribute to depression. By delivering L-methylfolate, the active form of folate, Deplin® supports the production of essential neurotransmitters like serotonin and dopamine, both of which are critical for mood regulation. In addition to supporting neurotransmitter production, Deplin® helps restore overall brain chemistry, impacting mood and cognition.3 This broad support enhances the brain's ability to respond to antidepressants, making them more effective. By helping to rebalance critical brain functions, Deplin® complements your antidepressant and supports a comprehensive approach to managing depression.
Yes, Deplin FC™ contains L-methylfolate (active form of folate) which helps boost your brain’s ability to work together with your antidepressant – without adding side effects.
Deplin FC™ starts working quickly when added to an antidepressant. Some people notice improvements in symptoms in as little as 30 days. Clinical trials show that over half of people achieved remission by 12 months.3,14 Everyone’s experience may differ, so it’s important to stay consistent and work with your healthcare provider to track your progress.
Deplin FC™ is generally well-tolerated, with a safety profile comparable to a placebo. Unlike common antidepressants, it is not associated with side effects like weight gain, sleep disturbances, or sexual dysfunction,1 making it a safe option to add into your depression care routine.
The length of time you may need to take Deplin FC™ depends on your individual needs. Many people use it long-term alongside antidepressants to maintain brain health and support mood balance. Clinical trials have shown that over half of individuals who used Deplin FC™ along with an antidepressant achieved remission by 12 months.3,14 Your healthcare provider will help you determine the best plan for you.
Deplin FC™ is free from major allergens such as fish, shellfish, wheat, eggs, milk, tree nuts, peanuts, soy, and sesame. It is also non-GMO, vegan, and contains no dyes, sugar, titanium dioxide, or preservatives.
Yes, Deplin FC™ is safe for long-term use under the guidance of a healthcare provider. The Deplin® brand has been supporting people with depression for over 15 years, with a proven track record of safety and effectiveness.
Deplin FC™ contains L-methylfolate, the biologically active form of folate, which helps address neurotransmitter imbalances in the brain. While the formulation includes other ingredients to support formulation stability, L-methylfolate is the key nutrient—in a form your body can use right away—to support emotional well-being.