Healthcare Professionals
Deplin FC™

Deplin FC™

Find what your “better” can be by adding Deplin FC™ to your depression care routine

Depression can feel overwhelming, especially if you’re on antidepressants and still seeking progress. There is hope. Deplin FC™ supports your brain’s ability to produce natural mood-boosting chemicals, working with your antidepressant to enhance your mood.1 It is “free & clear” of major allergens† and unnecessary additives.

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Ingredients

Microcrystalline Cellulose, Silicon Dioxide, Vegetarian Capsule (Hypromellose, Black Iron Oxide Ink), L-methylfolate Calcium (as Metafolin®), and Magnesium Stearate.

Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.

Manufactured & Distributed by: Alfasigma USA, Inc., Shreveport, LA 71103

Directions & Dosage

Adults and children 12 years of age and older, take one capsule daily or as directed by your healthcare provider.

Deplin FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression and schizophrenia.

Available in 15 mg and 7.5 mg capsules, in 90-count packages.

Warnings & Storage

Keep out of reach of children. If you are pregnant or nursing, consult with your healthcare provider before taking.

Store at a controlled room temperature of 59°F to 86°F (15°C to 30°C). Protect from heat, light, and moisture.

Addressing 3 Key Factors of Depression Management

Together, the ingredients in Deplin FC™ work to support:

Emotional Balance1,3
Helps maintain neurotransmitter activity — the brain chemicals that influence how you feel.
Brain Cell Wellness1
Provides nutrients that help protect brain cells from everyday oxidative stress and support normal cell function.
Cognitive Function1,12
Supports neuroplasticity — the brain’s ability to form and strengthen connections — to aid memory and clear thinking.

The Clinical Impact of Adding Deplin FC™ for Depression

L-methylfolate — the key nutrient in Deplin FC™ — has been shown in clinical studies to help enhance the body’s response to antidepressant treatment. It does not replace an antidepressant, but helps your brain use treatment more effectively.

1 in 2

People achieved remission at month 12.32

84% Symptom Reduction

Clinically shown to reduce depressive symptoms by up to 84% vs. an antidepressant alone.29

30 Days

Some symptoms can improve in as little as 30 days.29

No Added Side Effects

Safety profile is similar to placebo and not associated with weight gain or sexual dysfunction.29,32
Statistic about depression and dietary folic acid on a purple background

Why Folate Matters for Brain Health

Folate is an essential nutrient your brain uses to produce mood-regulating chemicals like serotonin, dopamine, and norepinephrine. Up to 70% of people with depression may have trouble converting folic acid from food into the active form your body can use, which the brain needs to function properly.3

Deplin FC™ delivers L-methylfolate directly, helping ensure your brain gets what it needs to support emotional well-being, without adding side effects like weight gain or sexual dysfunction.29

No Major Allergens or Unneeded Additives

The FC in Deplin FC™ stands for “Free & Clear," meaning it doesn’t have added ingredients to which your body or brain might be sensitive. DEPLIN® is the #1 prescribed medical food brand for depression* and it’s safe to start as soon as you start taking your antidepressant.

Getting Deplin FC™ through Brand Direct Health® Pharmacy is easy

  • Everyday low price
  • Flexible payment options
  • 100% money-back guarantee
  • FSA/HSA eligibility
  • Brand Direct Health® Pharmacy orders only, as compared to the everyday retail price through GoodRx (accessed on 6/24/2024).
    Limited to 1 refund per person, per product. Excludes shipping and convenience fees.

Deplin FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression & schizophrenia. Use under medical supervision.

DeplinPRO Mood Health™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of mood disorders. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) and DeplinPRO Mood Health™are free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of Deplin® branded medical foods compared to other branded medical foods indicated for depression.

§Real testimonials. Pictures and names are for illustrative purposes only.

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