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See how Deplin® helps with depression care

Targeted nutrition plays a key role in depression care. Deplin® helps restore neurotransmitter homeostasis, helping the brain and antidepressants work better together.1
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Why Consider Deplin®

Helps address nutritional deficiencies linked to depression4
Delivers bioactive L-methylfolate to aid neurotransmitter production1
Complements standard antidepressant therapy

The Role of Nutrition in Mood

Key nutrients like folate are crucial for neurotransmitter synthesis and brain health, supporting mood balance and cognitive function. Deficiencies in essential nutrients can negatively impact mood and hinder treatment response, making targeted nutritional support an important consideration in depression care. 1,4, 5
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How Deplin® Works

Deplin® provides L-methylfolate, which helps restore neurotransmitter balance and modulate glutamate levels in the brain. This can enhance the brain's natural ability to regulate mood and cognition, allowing the brain and antidepressants to work better together.1, 4
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Efficacy & Safety

Clinical studies have shown that adding Deplin® to antidepressant therapy delivers positive outcomes for patients with major depressive disorder.

Significantly greater symptom improvement vs. SSRI alone3

Sustained remission12

Safety profile similar to placebo3

High patient satisfaction and compliance15

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Your Partner in Depression Care

Deplin® has been supporting patients with depression for more than 15 years. It’s the #1 prescribed medical food brand for depression.*
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DEPLIN FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression and schizophrenia. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) is free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of branded medical foods indicated for Depression.

  1. Liwinski T, Lang UE. Nutrients. 2023;15(17):3859.
  2. Mrozek W, et al. Nutrition. 2023:112143.
  3. Papakostas G, et al. Am J Psychiatry. 2012;169:1267-1274.
  4. Lam NSK, et al. Biomedicine & Pharmacotherapy. 2022;146:112541.
  5. Fava M, Mischoulon D. J Clin Psychiatry.2009;70(suppl 5):12-17.
  6. Nakazato M. et al.Eur J Nutr. 2011; 50:581–585.
  7. Ginsberg LD, et al.Innov Clin Neurosci. 2011;8(1):19-28.
  8. Sobczynska-Malefora A. et al.Blood Coagul Fibrinolysis. 2009;20(4):297-302.
  9. Stahl SM et al. J ClinPsychiatry. 2008;69(9):1352-1353.
  10. Petridou ET et al.Aging Ment Health. 2015;8:1-9.
  11. Beaudin AE, et al.BirthDefects Res A Clin Mol Teratol. 2009 Apr;85(4):274-84
  12. Zajecka JM, et al. J Clin Psychiatry. 2016 ;77(5) :654-660.
  13. Willems FF et al.Br J Pharmacol.2004;141(5):825-830.
  14. Stahl SM. CNS Spectr 2007;12(10):739-44.