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Deplin FC™

Help your patients find their “better” by adding Deplin FC™ to their depression care routine.

Deplin FC™ is targeted nutrition specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression. The formula creates an optimal environment in the brain so patients can get the most out of their antidepressant. It is free and clear from major allergens† and unnecessary additives.
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What is Deplin FC™?

Ingredients

Microcrystalline Cellulose, Silicon Dioxide, Vegetarian Capsule (Hypromellose, Black Iron Oxide Ink), L-methylfolate Calcium (as Metafolin®), and Magnesium Stearate.

Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.

Manufactured & Distributed by:Alfasigma USA, Inc., Shreveport, LA 71103

Directions & Dosage

Adults and children 12 years of age and older, take one capsule daily or as directed by your healthcare provider.

Available in 15 mg and 7.5 mg capsules, in 90-count packages.

Warnings & Storage
Keep out of reach of children. If you are pregnant or nursing, consult with your healthcare provider before taking.

Store at a controlled room temperature of 59°F to 86°F (15°C to 30°C). Protect from heat, light and moisture.

The Deplin FC™ Advantage

Deplin FC™ provides bioactive L-methylfolate, which crosses the blood-brain barrier in one step, to restore neurotransmitter balance and support brain function.4

When added to antidepressant treatment, it enhances patient outcomes by addressing key nutritional deficiencies that can impact treatment response.

See Clinical Studies

  • Addresses Nutritional Deficiencies
    Targets factors affecting depression and treatment response.1,4
  • Enhances Antidepressant Response
    Supports neurotransmitter balance and brain function.1, 4, 5
  • Helps Optimize Depression Care
    Aims to improve patient outcomes.3
  • Well-Tolerated
    Safety profile comparable to placebo.3
  • Long Heritage
    Used by healthcare providers for over 15 years.

How Deplin FC™ Works

Neurotransmitter balance plays a key role in mood regulation. See how Deplin FC™ supports brain chemistry.1, 4, 5

Normal Brain

Mood is controlled by the presence of neurotransmitters (dopamine, norepinphrine, and seretonin) and the modulation of glutamate.

During Depression

Neurotransmitter dysregulation and dysfunction of the complex neural networks that regulate mood cognition and stress response can occur due to low levels of L-methylfolate.

Antidepressant treatment

Antidepressants inhibit the reuptake of certain neurotransmitters and alleviate symptoms by making the best use of the available neurotransmitters.

Antidepressant + Deplin FC™

The L-methylfolate in Deplin FC™ boosts the body's ability to produce normal amounts of neurotransmitters and modulate glutamate levels helping brain neurochemistry and antidepressants work better together.

Free & Clear Formula

Deplin FC™ contains no major allergens and unnecessary additives.

Patient Resources

Download and print these tools to support your patients on their depression care journey.
doctor discussion guide for adults 18 plus

Patient Discussion Guide (Adults)

This guide can help you and your patient discuss their depression symptoms, treatment, and whether adding Deplin® is right for them.
Download

Patient Discussion Guide (Adolescents)

This guide can help you and your patient discuss their depression symptoms, treatment, and whether adding Deplin® is right for them.
Download
More Resources
Become a Prescriber

DEPLIN FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression and schizophrenia. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) is free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of branded medical foods indicated for Depression.

  1. Liwinski T, Lang UE. Nutrients. 2023;15(17):3859.
  2. Mrozek W, et al. Nutrition. 2023:112143.
  3. Papakostas G, et al. Am J Psychiatry. 2012;169:1267-1274.
  4. Lam NSK, et al. Biomedicine & Pharmacotherapy. 2022;146:112541.
  5. Fava M, Mischoulon D. J Clin Psychiatry.2009;70(suppl 5):12-17.
  6. Nakazato M. et al.Eur J Nutr. 2011; 50:581–585.
  7. Ginsberg LD, et al.Innov Clin Neurosci. 2011;8(1):19-28.
  8. Sobczynska-Malefora A. et al.Blood Coagul Fibrinolysis. 2009;20(4):297-302.
  9. Stahl SM et al. J ClinPsychiatry. 2008;69(9):1352-1353.
  10. Petridou ET et al.Aging Ment Health. 2015;8:1-9.
  11. Beaudin AE, et al.BirthDefects Res A Clin Mol Teratol. 2009 Apr;85(4):274-84
  12. Zajecka JM, et al. J Clin Psychiatry. 2016 ;77(5) :654-660.
  13. Willems FF et al.Br J Pharmacol.2004;141(5):825-830.
  14. Stahl SM. CNS Spectr 2007;12(10):739-44.