Healthcare Professionals

Why Deplin®

Nutrition influences the biochemical processes that support mood. For people with depression whose nutritional needs cannot be met through dietary changes alone, DEPLIN® offers a clinical option as part of their overall depression care.

Rebalancing Your Brain

People with depression have a higher nutrient demand related to genetic or other metabolic factors. These increased needs often can’t be met by changes in diet alone, leaving the brain’s mood-regulating biological processes without adequate support. When these processes are affected, it can influence how you feel and how your brain responds to treatment.

DEPLIN® provides targeted medical nutrition to help address these nutritional needs and support the biological processes involved in regulating mood.

How DEPLIN® Works

In a person without depression1,3-5,10

Mood is controlled by complex interactions among natural brain chemicals called neurotransmitters.

During Depression1,6,8,13

The brain may not make enough neurotransmitters or their levels may be unbalanced. This could be due to higher nutritional demands.

Depression treatment1,14

Antidepressants ease symptoms by helping your brain make the best use of available neurotransmitters. However, many people with depression still have lower-than-normal levels, which limits what the brain has to work with and means that chemical balance may not be fully restored.

Adding DEPLIN® 1,3,6,8,10,13

The ingredients in DeplinPRO Mood Health™ and Deplin FC™ help restore brain chemistry and support the biological foundation your brain needs for effective treatment response.

Meet the DEPLIN® Products

Both DeplinPRO Mood Health™ and Deplin FC™ are medical foods that provide targeted nutrition designed to help restore the brain chemistry balance your brain depends on for mood and treatment response.
Two bottles of Deplin products showing the multi nutrient versus single-nutrient support to support 5 factors versus 3 factors of depression

When key nutrients run low, brain chemistry can lose balance

Research shows that people with depression may have lower levels of nutrients like folate (as L-methylfolate), vitamin D₃, and zinc6,15,16—these essential nutrients help restore brain-chemistry balance.

When levels are low, the brain can struggle to support mood and effective treatment response. Genetics, health conditions like diabetes, medications, and even alcohol use can affect how your body uses these nutrients, which means changes in diet alone are not always enough.

Factors contributing to low levels of folate, vitamin D3, and zinc.

Genetic Factors17-19

Many people have genes that make it harder to activate nutrients like folate, vitamin D₃, and zinc — important for mood and brain function.

Diet & Weight17,18,20,22

Poor diet and increased weight can affect how well your body absorbs and uses important nutrients like folate, vitamin D₃, and zinc.

Aging & Metabolism20,22,23

Your ability to process & absorb nutrients slows as you age, making it harder to maintain nutrient levels.

Lifestyle & Environment17,20,22,24,25

Limited sun, high stress, smoking, alcohol are just some things that affect how well your body absorbs nutrients.

Medication15,18,24-26

Some medications—for diabetes, seizure or birth control—can reduce nutrient levels like folate, vitamin D3, and zinc.

Health Conditions17,20,22,28

Diabetes, digestive disorders, thyroid issues and other condition can affect how nutrients are absorbed.

DEPLIN® Adds to Your Depression Care Without Adding Side Effects

In clinical studies, the ingredients in both DeplinPRO Mood Health™ and Deplin FC™ were shown to be safe and well-tolerated, meaning DEPLIN® can support your journey toward improved mental well-being without disrupting your life.10,29-33

Deplin FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression & schizophrenia. Use under medical supervision.

DeplinPRO Mood Health™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of mood disorders. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) and DeplinPRO Mood Health™are free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of Deplin® branded medical foods compared to other branded medical foods indicated for depression.

§Real testimonials. Pictures and names are for illustrative purposes only.

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