Healthcare Professionals

Why Deplin®

Deplin® is targeted nutrition that replenishes a key nutrient to help restore brain chemistry for mood regulation, cognitive function, and overall well-being. This targeted nutrition helps your brain and antidepressant work better together.1

Rebalancing Your Brain

The L-methylfolate (active form of folate) in Deplin® supports your brain’s production of mood-regulating neurotransmitters like serotonin, dopamine, and norepinephrine. Antidepressants rely on these chemicals to work effectively, but up to 70% of people with depression struggle to convert dietary folic acid into usable folate.1-2 Deplin® addresses this by providing a ready-to-use form of folate to help rebalance brain chemistry and support emotional well-being.

How Deplin® Works1,4,5

Depressed Brain

Low levels of L-methyfolate can disrupt brain chemical production, affecting mood.

Antidepressants

Antidepressants relieve depression symptoms by enhancing the brain chemicals that already exist.

Antidepressant + Deplin®

L-methylfolate in Deplin® boosts the brain’s ability to produce more mood-enhancing brain chemicals for the antidepressant to act on.1,4,5

Factors contributing to low levels of folate in depression1,4-11

Genetic Factors

Up to 70% of people with depression may not be able to activate dietary folic acid.

Medication

Various medications may impact folate levels such as antimicrobials, anti-epileptics, and oral contraceptives.

Comorbidities

Diabetes, gastrointestinal disorders, and hypothyroidism.

Aging

Decreasing levels of folate with increasing age in depression.

Lifestyle & Environment

Excessive alcohol consumption, smoking, poor nutrition, and pregnancy.

Weight

Increased body mass index may be associated with reduced folate levels.

Depression Care Without Added Side Effects

In clinical trials, Deplin® was shown to be as safe as the placebo (sugar pill), meaning it’s well-tolerated and can support your journey toward improved mental well-being without disrupting your life. Deplin® is not associated with weight gain or sexual dysfunction.3,12
Get a Prescription

Deplin®/Deplin FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression and schizophrenia. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) is free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of Deplin® branded medical foods compared to other branded medical foods indicated for depression.

  1. Liwinski T, Lang UE. Nutrients. 2023;15(17):3859.
  2. Mrozek W, et al. Nutrition. 2023:112143.
  3. Papakostas G, et al. Am J Psychiatry. 2012;169:1267-1274.
  4. Lam NSK, et al. Biomedicine & Pharmacotherapy. 2022;146:112541.
  5. Fava M, Mischoulon D. J Clin Psychiatry.2009;70(suppl 5):12-17.
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  17. Lam RW, et al. Can J Psychiatry. 2024 May 6:1-47