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The Data Behind Deplin®

Proven Efficacy, Patient Satisfaction & Safety

The study results listed here are just a snippet of the clinical data available that support using Deplin® along with an antidepressant for depression. With targeted nutrition in the active form of folate, L-methylfolate, you can give your patient hope even if their antidepressant isn’t yet relieving their depression symptoms.

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Safe and Well Tolerated for Depression Care

In clinical studies, Deplin® was shown to be well-tolerated by patients taking antidepressants, with a safety profile similar to placebo. There was no significant difference in discontinuation and Deplin® was not associated with weight gain or sexual dysfunction.3, 12

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DEPLIN FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression and schizophrenia. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) is free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of branded medical foods indicated for Depression.

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  2. Mrozek W, et al. Nutrition. 2023:112143.
  3. Papakostas G, et al. Am J Psychiatry. 2012;169:1267-1274.
  4. Lam NSK, et al. Biomedicine & Pharmacotherapy. 2022;146:112541.
  5. Fava M, Mischoulon D. J Clin Psychiatry.2009;70(suppl 5):12-17.
  6. Nakazato M. et al.Eur J Nutr. 2011; 50:581–585.
  7. Ginsberg LD, et al.Innov Clin Neurosci. 2011;8(1):19-28.
  8. Sobczynska-Malefora A. et al.Blood Coagul Fibrinolysis. 2009;20(4):297-302.
  9. Stahl SM et al. J ClinPsychiatry. 2008;69(9):1352-1353.
  10. Petridou ET et al.Aging Ment Health. 2015;8:1-9.
  11. Beaudin AE, et al.BirthDefects Res A Clin Mol Teratol. 2009 Apr;85(4):274-84
  12. Zajecka JM, et al. J Clin Psychiatry. 2016 ;77(5) :654-660.
  13. Willems FF et al.Br J Pharmacol.2004;141(5):825-830.
  14. Stahl SM. CNS Spectr 2007;12(10):739-44.