What Is DEPLIN®

DEPLIN® is targeted nutrition for people with depression, sold by prescription, and can be used with your current antidepressant. It contains L-methylfolate, an active form of folate, which is one of the body’s essential B vitamins. By enhancing folate levels in the brain, DEPLIN® helps the brain and your current antidepressant work better together.1

If you have depression, your body may need more active folate. Low levels of active folate can make it harder to see results from your antidepressant. Not having enough active folate may also put you at risk of your depression coming back, even after it has gone away.2

DEPLIN® is prescribed by healthcare professionals and should only be used under medical supervision. Please talk to your healthcare provider or request a rapid assessment to determine if DEPLIN® is right for you.

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#1 Prescribed Medical Food Brand for Depression*


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*Based on US dollar sales through IQVIA NSP reporting channels from October 2021-September 2023 of Deplin® compared to other branded medical foods indicated for Depression.

References: 1. Papakostas GI, et al. American Journal of Psychiatry. 2012;169(12):1267-1274. 2. Stahl SM. CNS Spectr 2007;12(10):739-44.


DEPLIN® is a medical food for use only under medical supervision for the clinical dietary management of depression and schizophrenia and is specially formulated to meet the distinctive nutritional requirement for these condition.

Manufactured and Distributed by:
Alfasigma USA, Inc.
Shreveport, LA 71104
© 2024 Alfasigma USA, Inc.


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