Healthcare Professionals
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Deplin® helps your brain and antidepressant work better together

Targeted nutrition for people with depression

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See how nutrients can support mood.

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Add Deplin® to your depression care.

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What is Deplin®?

Deplin® is targeted nutrition that provides an essential nutrient your body can’t get through diet alone to help restore brain chemistry balance. This allows your brain and antidepressant to work better together for more effective symptom relief.1 Deplin® is prescribed for use under medical supervision.

How Nutrition Impacts Mood

Proper nutrition plays a key role in mood and brain function. Nutrient deficiencies can interfere with cognitive performance and emotional well-being. Without the right nutrients, antidepressants may not work optimally, and side effects may increase. Addressing these deficiencies helps restore brain chemistry balance and supports recovery.2

Is Deplin® Right For You?

Deplin® is the #1 prescribed medical food brand for depression*. Ask your healthcare provider if Deplin® should be added to your current depression care.

Free & Clear

Deplin® offers Deplin FC™, a free and clear formula that provides 15mg of L-methylfolate to help your brain and antidepressant work better together.1,4

84% Symptom Reduction

In a clinical study, adding Deplin FC™ reduced depressive symptoms by up to 84% vs antidepressant alone. 3

No Added Side Effects

Safety profile is similar to placebo and not associated with weight gain or sexual dysfunction. 13

Deplin® & Depression Resources

Patient Resources

Download a discussion guide to start the conversation with your provider, and find other resources on Deplin® and depression.
See Patient Resources

Request a Prescription

If you’re using an antidepressant but still not feeling your best, connect with a provider via telehealth to see if Deplin® can help you.
Request a Prescription

What people are saying§

"I love the product! It works so well for me...It made such a difference!"
"You guys should hire me to promote Deplin. It changed my life!" "I've been taking it for about 10 years...I have nothing but great things to say about Deplin. It seriously saved my life[.]"
"It's working! I'm happy to be taking it and happy with the results!"
"I've been on [Deplin] for almost three years and it has been an absolute godsend."
"You all are changing lives...After a DNA test, I found out, my body cant metabolize folate and when I started taking this, it changed everything."
"It’s a great product. I've used it for a while and it's helped me so much." "[Deplin] has really helped me...great product and very effective."
"Great [product]. It's made such a difference in my life."
"I started taking this when I was in a very dark place. I am so grateful[.]"
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Deplin®/Deplin FC™ is a medical food specially formulated to meet the distinctive nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression and schizophrenia. Use under medical supervision.

†Deplin FC™ (FC for “free & clear”) is free from major allergens: milk, eggs, fish or shellfish, sesame, tree nuts, peanuts, wheat, and soy.

*Based on US dollar sales through IQVIA NSP reporting channels from January 2023 – December 2024 of Deplin® branded medical foods compared to other branded medical foods indicated for depression.

§Real testimonials. Pictures and names are for illustrative purposes only.

  1. Liwinski T, Lang UE. Nutrients. 2023;15(17):3859.
  2. Mrozek W, et al. Nutrition. 2023:112143.
  3. Papakostas G, et al. Am J Psychiatry. 2012;169:1267-1274.
  4. Lam NSK, et al. Biomedicine & Pharmacotherapy. 2022;146:112541.
  5. Fava M, Mischoulon D. J Clin Psychiatry.2009;70(suppl 5):12-17.
  6. Nakazato M. et al.Eur J Nutr. 2011; 50:581–585.
  7. Ginsberg LD, et al.Innov Clin Neurosci. 2011;8(1):19-28.
  8. Sobczynska-Malefora A. et al.Blood Coagul Fibrinolysis. 2009;20(4):297-302.
  9. Stahl SM et al. J ClinPsychiatry. 2008;69(9):1352-1353.
  10. Petridou ET et al.Aging Ment Health. 2015;8:1-9.
  11. Beaudin AE, et al.BirthDefects Res A Clin Mol Teratol. 2009 Apr;85(4):274-84
  12. Zajecka JM, et al. J Clin Psychiatry. 2016 ;77(5) :654-660.
  13. Willems FF et al.Br J Pharmacol.2004;141(5):825-830.
  14. Stahl SM. CNS Spectr 2007;12(10):739-44.
  15. Shelton RC, et al. Prim Care Companion CNS Disord. 2013 Aug 29;15(4). https://pmc.ncbi.nlm.nih.gov/articles/PMC3869616/
  16. Sarris J. et al. World J Biol Psychiatry. 2022;23(6):424-455.
  17. Lam RW, et al. Can J Psychiatry. 2024 May 6:1-47